Cardiac disease and erectile dysfunction frequently coexist. Sexual activity, being physical activity, carries a potential cardiac risk for those patients with pre-existing cardiac disease. This risk may include the triggering of a myocardial infarction due to the increase in cardiac workload associated with sexual activity. Therefore, it is generally considered unwise for any patient with unstable cardiovascular disease to engage in sexual activity, regardless of whether they have taken a PDE5 inhibitor. Unstable cardiovascular disease is defined as: unstable or refractory angina; uncontrolled hypertension; congestive heart failure (Class III or IV); very recent MI (<2 weeks); high-risk arrhythmias; obstructive cardiomyopathies; moderateto- severe valvular disease [52]. Sexual intercourse requires 3 to 4 METS (Metabolic Equivalent of the Tasks) of energy expenditure. This energy requirement is approximately equivalent to walking at a rate of 3 MPH (or one mile in 20 minutes on level ground) [53]. Accordingly, the physical demands of intercourse can generally be considered safe for a patient who can walk comfortably one mile in 20 minutes without notable symptoms.
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