Can my patients take tadalafil with statins?

Yes, tadalafil may be prescribed in men taking  statins (HMG-CoA reductase inhibitors) to lower  cholesterol. Co-administration of tadalafil with  statins is well tolerated with no evidence of  increased adverse events, including back pain  and myalgia. Also, in a clinical pharmacology  study there was no clinically significant pharmacokinetic  interaction when tadalafil and  lovastatin (Mevacor1) were co-administered.  Specifically tadalafil 20 mg did not increase  plasma concentrations of lovastatin.  In an integrated placebo-controlled tadalafil  database involving 2945 subjects, 388 men  (13.2%) received statins simultaneously with  study drug. The relatively high proportion of  men treated with statins in this population of  males with erectile dysfunction is not surprising,  because hyperlipidemia is a prominent  risk factor for ED. A detailed analysis of this  large population of men taking tadalafil concomitantly  with HMG-CoA reductase inhibitors  has indicated that the administration of  statins does not increase the relative risk of  back pain, myalgia, or pain in limb in tadalafiltreated  patients (10 and 20 mg) relative to  placebo-treated patients.