Has priapism been reported with tadalafil therapy?

In the over 100 clinical trials completed to  date (involving more than 12,000 patients)  no reports of priapism have been observed.  Rare reports of priapism have been reported  following the administration of other PDE5  inhibitors. There have been rare reports of  priapism in post-marketing surveillance of  tadalafil. PDE5 inhibitors should be prescribed  with caution in patients who have conditions  that might predispose them to priapism  (sickle cell anemia, multiple myeloma, or  leukemia).