Tadalafil can be prescribed to men with ED who are on one or more antihypertensives, with the exception of those alpha-blockers which are used to treat hypertension. However, appropriate clinical advice should be given to patients regarding a possible decrease in blood pressure when they are being treated with antihypertensive medications and taking a PDE5 inhibitor. Tadalafil has been studied with concomitant use of antihypertensive medications because many patients who experience erectile dysfunction also have hypertension. Specific drug-interaction studies, examining the use of tadalafil and commonly prescribed oral antihypertensive agents, and extensive safety data from patients taking tadalafil and oral antihypertensives concomitantly, demonstrate that tadalafil is generally safe in patients receiving one or more concomitant antihypertensive agents [61,62]. Studies have been conducted to test the interaction of tadalafil with antihypertensive agents including amlodipine besylate (Norvasc1), metoprolol (Toprol-XL1), bendrofluazide, enalapril maleate (Vasotec1), or angiotensin II receptor blockers. No clinically significant interactions were observed.
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