Yes. The risk of ED is 4-fold higher in men with diabetes and approximately 50% of men with diabetes mellitus have ED [36]. Although the causes of ED in diabetes mellitus are multifactorial, at least two major mechanisms are involved –endothelial dysfunction of the penile microvasculature and neuropathy of the nerve fibers that innervate the penis. The efficacy of tadalafil has been evaluated in 637 men with Type 1 and Type 2 diabetes (HbA1C [1] 13%) [37]. Treatmentwithtadalafil significantlyimproved erectile function in men with diabetes regardless of baseline HbA1C levels or type of diabetes therapy (insulin, oral agents, or diet alone). The mean proportion of successful intercourse attempts in these patients with diabetes was 53% (tadalafil 20 mg) and 49% (tadalafil 10 mg) compared to 22% of patients receiving placebo (p < 0.001).
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