Does tadalafil work in older men with ED?

 Yes. In an analysis of 11 integrated studies  where 23% of men were over age 65 [23], the  mean change in IIEF EF Domain scores from  baseline to endpoint for men [1]65 taking tadalafil  20 mg was 8.8. For men >65, the mean  change from baseline was 8.0. For men taking  tadalafil 10 mg, the mean change from baseline  to endpoint was 6.6 ([1]65 y) and 6.3 (>65 y)  (p < 0.001 for all comparisons of tadalafil to  placebo). The mean changes from baseline to  endpoint for the two age groups were not  significantly different (p = 0.74). Thus, the  response to tadalafil was not influenced by age.  Supplement  148 Vol. 2, No. 1, pp. 141–157, March 2005  III. Maximizing Tadalafil Therapy