Does a man with ED need to ‘‘time’’ his dosing of tadalafil prior to anticipating sexual intercourse?

For other oral PDE5 inhibitors, patients must  plan to have sexual intercourse soon after taking  their medication, typically within 4 hours.  In contrast, tadalafil has been shown to be  efficacious up to 36 hours after dosing. Therefore,  patients are not required to engage in  sexual intercourse soon after taking tadalafil.  In a recent study ofmenfrom the US and Puerto  Rico, patients treated with tadalafil 20 mg were  receptive to the 36-hour duration, and the  majority (55.2%) of intercourse attempts  occurred between 4 and 36 hours after dosing  [34]. Intercourse success during the interval 4–  36 hours was 71% for patients treated with  tadalafilcompared to 18% for patients receiving  placebo [34]. For example, in France, tadalafil  has been dubbed ‘‘le weekend’’ drug based on  the strategy of taking the drug Friday afternoon  or evening in advance of anticipated sexual  relations during the weekend.