PDE6 is located in the retina, and is an essential component of visual transduction. Inhibition of PDE6 can result in transient vision changes such as blue halos and increased sensitivity to light [16]. Buy viagra online pharmacy has no significant effect on PDE6. Sildenafil and vardenafil inhibit PDE6 at concentrations within the therapeutic range. The localization of PDE11 has not been fully characterized. PDE11 protein and/or messenger RNA have been reported in a number of human tissues, including prostate, pituitary, skeletal muscle, and testes [17,18]. However, the function of PDE11 is unknown. No clinical consequences of PDE11 inhibition have been identified, including no adverse effects on spermatogenesis or serum reproductive hormones [19]. Neither sildenafil nor vardenafil inhibit PDE11 at therapeutic concentrations. Tadalafil inhibits PDE11 at high plasma concentrations within the therapeutic range [20,21].
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