Erectile dysfunction (ED) is a topic of considerable importance to men’s health. In men with cardiovascular disease and diabetes mellitus especially, ED is increasingly being recognized as a comorbid condition. ED is a treatable condition, but some treatment options—sex therapy, implants, vacuum devices, intracavernosal injections, and herbal medications and creams—could be time consuming, painful, awkward, or of questionable efficacy. The advent of oral phosphodiesterase 5 (PDE5) inhibitors has revolutionized the treatment of men with ED.